首頁資訊大黃不同功效的古今用藥規(guī)律分析

大黃不同功效的古今用藥規(guī)律分析

來源：泰然健康網(wǎng) 時間：2024年12月15日 19:59

[關(guān)鍵詞]

[摘要]

基于文本數(shù)據(jù)挖掘研究，分析歸納大黃不同功效的古今用藥規(guī)律。將中醫(yī)方劑數(shù)據(jù)庫中含有大黃的7 226首古方與《中國藥典》2015年版和藥智網(wǎng)中含有大黃的736條現(xiàn)代中成藥處方信息分別進行篩選歸納，統(tǒng)計大黃在方劑中占比、制法、配伍藥、功效及所治疾病科屬，探究大黃制法用法與功效、疾病科屬間的聯(lián)系。通過數(shù)據(jù)挖掘發(fā)現(xiàn)，除生用內(nèi)服、最常用于治療內(nèi)科疾病外，大黃發(fā)揮"瀉下攻積、清熱瀉火"作用時古代常水煎液內(nèi)服，現(xiàn)多酒炙內(nèi)服，還用于兒科；"涼血解毒"時古代常貼膏外用或水煎液內(nèi)服，現(xiàn)多醇提內(nèi)服，還用于外科；"逐瘀通經(jīng)"時古方中以酒煎液或酒送服為主，現(xiàn)今以水煎液內(nèi)服為主，較多用于婦科；"利濕退黃"時古代常水煎液內(nèi)服，而現(xiàn)代以酒煎液或水酒共煎液居多，還用于兒科。古方中大黃多與甘草配伍而現(xiàn)代與黃芩配伍較多，在"逐瘀通經(jīng)"中配伍藥古方以當歸、肉桂、木香為主，現(xiàn)代以芍藥和干漆為主。這些研究結(jié)果為大黃的臨床精準使用與相關(guān)藥物創(chuàng)制提供了參考。

[Key word]

[Abstract]

This paper analyzes and summarizes the multifunctional regularity of Rhei Radix et Rhizoma (rhubarb) in ancient and modern medicine based on text data mining approach. The 7 226 ancient prescriptions containing rhubarb in traditional Chinese medicine prescription database and 736 formulas of modern Chinese medicine prescriptions containing rhubarb in Chinese Pharmacopoeia (2015 edition) and Yaozhi network were screened and summarized respectively. The proportion of rhubarb in prescriptions, preparation methods, compatibility drugs, efficacy and disease attributions were determined, and the relationships between rhubarb preparation methods and efficacy, disease attributions were also explored. Through data mining, in addition to direct oral administration and mostly being used for the treatment of internal medicine diseases, rhubarb was orally taken with water decoction in ancient times while wine-treated rhubarb now commonly used in pediatrics as well to remove accumulation with purgation and clear heat and purge fire. When rhubarb plays a role in cooling blood and detoxifying, it was often used externally or taken in the form of water decoction in the past. In modern times, rhubarb is usually taken in by alcohol extraction method, and is also applied in surgery. To eliminate blood stasis and remove obstruction in the channels, wine decoction or taken with wine was used primarily in ancient times while taken orally with water decoction is focused on today, mainly for gynecology. For eliminating dampness and removing jaundice, rhubarb was mostly used orally with water decoction in the past instead of wine decoction or wine and water co-decoction nowadays, and mainly used for treating pediatric diseases. In ancient prescriptions, rhubarb was often combined with Glycyrrhizae Radix et Rhizoma and now used with Scutellariae Radix. In the efficacy of eliminating blood stasis, compatibility drugs were focused on Angelicae Sinensis Radix, Cinnamomi Cortex, and Aucklandiae Radix in the past and used mostly with Paeoniae Radix and Toxicodendri Resina today. These findings provide reference for the accurate clinical use of rhubarb and the creation of related drugs.

[中圖分類號]

R28

[基金項目]

國家自然科學基金項目（81603258）；陜西省高校科協(xié)青年人才托舉計劃項目（20180307）