健康的生活方式可降低有妊娠高血壓遺傳傾向婦女的心血管風險

Sang?Hyuk Jung, Haemin Kim, Young Mi Jung, Manu Shivakumar, Brenda Xiao, Jaeyoung Kim, Beomjin Jang, Jae-Seung Yun, Hong-Hee Won, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Dokyoon Kim, Seung Mi Lee

摘要

妊娠期高血壓疾病的遺傳風險與動脈粥樣硬化性心血管疾病的發(fā)展有關。然而，生活方式和代謝綜合征對動脈粥樣硬化性心血管疾病的影響尚未得到評估。在這里，我們評估了這些因素與有妊娠期高血壓疾病遺傳風險的女性動脈粥樣硬化性心血管疾病之間的長期關聯(lián)。我們使用來自大規(guī)模GWAS的全基因組多基因風險評分來評估妊娠期高血壓疾病的遺傳風險。動脈粥樣硬化性心血管疾病的發(fā)生率根據遺傳風險、生活方式和代謝綜合征來評估。妊娠期高血壓疾病遺傳風險高的個體發(fā)生動脈粥樣硬化性心血管疾病的幾率比遺傳風險低的個體高53.0%。然而，在高遺傳風險組（前20%）中，通過維持理想的代謝綜合征狀態(tài)和健康的生活方式，發(fā)生動脈粥樣硬化性心血管疾病的風險降低了64.6%，在低遺傳風險組（后20%）中，這一風險降低了65.4%。這些發(fā)現(xiàn)強調，保持健康的生活方式對降低動脈粥樣硬化性心血管疾病的風險同樣有效，而不依賴于妊娠期高血壓疾病的遺傳風險。

本文章由計算機程序翻譯，如有差異，請以英文原文為準。

Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy

The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated. Here, we assess the long-term association between these factors and atherosclerotic cardiovascular disease in women with genetic risk for hypertensive disorders of pregnancy. We evaluate the genetic risk for hypertensive disorders of pregnancy using a genome-wide polygenic risk score derived from a large-scale GWAS. The incidence of atherosclerotic cardiovascular disease is evaluated according to genetic risk, lifestyle, and metabolic syndrome. Individuals with a very high genetic risk for hypertensive disorders of pregnancy have a 53.0% higher chance of developing atherosclerotic cardiovascular disease than those with a low genetic risk. However, the risk of developing atherosclerotic cardiovascular disease is reduced by up to 64.6% through the maintenance of an ideal metabolic syndrome status and a healthy lifestyle in the high genetic risk group (top 20%), and by up to 65.4% in the low genetic risk group (bottom 20%). These findings emphasize that maintaining a healthy lifestyle in women is equally effective at reducing the risk of atherosclerotic cardiovascular disease independent of genetic risk for hypertensive disorders of pregnancy.

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來源期刊

期刊介紹： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.

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