首頁資訊大健康與精準(zhǔn)醫(yī)藥營養(yǎng)團(tuán)隊(duì)—王軍團(tuán)隊(duì)

大健康與精準(zhǔn)醫(yī)藥營養(yǎng)團(tuán)隊(duì)—王軍團(tuán)隊(duì)

來源：泰然健康網(wǎng) 時(shí)間：2024年12月08日 15:41

一、團(tuán)隊(duì)名稱

大健康與精準(zhǔn)醫(yī)藥營養(yǎng)團(tuán)隊(duì)

二、團(tuán)隊(duì)組成

負(fù)責(zé)人：王軍（博士、教授）

其他團(tuán)隊(duì)成員：全職副教授1名，講師2名；海內(nèi)外兼職教授3名（院士2名、國務(wù)院特殊津貼專家1名），海外兼職副教授3名

三、團(tuán)隊(duì)介紹

團(tuán)隊(duì)研究方向：自由基在急慢性疾病中的檢測、功能與機(jī)制的基礎(chǔ)與轉(zhuǎn)化研究

主要研究內(nèi)容：（1）孤獨(dú)癥譜系障礙中氧化應(yīng)激生物標(biāo)志物的鑒定與靈敏檢測；（2）自由基在神經(jīng)發(fā)育中的作用與機(jī)制；（3）自由基與炎癥因子風(fēng)暴的清除與藥物設(shè)計(jì)。團(tuán)隊(duì)固定教師10名，其中教授4人、副教授4人、講師2人。研究工作覆蓋神經(jīng)生物學(xué)、免疫學(xué)、生物化學(xué)、分子生物學(xué)與分析化學(xué)等學(xué)科交叉領(lǐng)域，在國際自由基生物醫(yī)學(xué)領(lǐng)域具有行業(yè)影響力。

團(tuán)隊(duì)依托科研平臺(tái)：國家外專局/教育部“細(xì)胞調(diào)控與分子藥物111引智基地” （科學(xué)研究）、發(fā)酵工程教育部重點(diǎn)實(shí)驗(yàn)室（科學(xué)研究）、大健康與精準(zhǔn)醫(yī)藥營養(yǎng)中心（成果轉(zhuǎn)化）。團(tuán)隊(duì)承擔(dān)了科研項(xiàng)目10項(xiàng)，省級(jí)基金項(xiàng)目4項(xiàng)，近三年研究項(xiàng)目近280萬元，發(fā)表SCI文章30余篇，授權(quán)發(fā)明專利5項(xiàng)，獲國內(nèi)國際獎(jiǎng)10余項(xiàng)。

四、科研成果

（1）代表性的科研項(xiàng)目：

湖北省高端人才啟動(dòng)基金項(xiàng)目“人體一氧化氮合成酶機(jī)理和功能的基礎(chǔ)研究”；

111引智基地國際合作項(xiàng)目“一氧化氮在巨噬細(xì)胞中的作用與機(jī)制”；

校企合作重大項(xiàng)目“孤獨(dú)癥兒童營養(yǎng)支持食品研發(fā)及產(chǎn)業(yè)化應(yīng)用”；

校企合作重大項(xiàng)目“特殊醫(yī)學(xué)用途食品中一氧化氮的檢測”。

（2）代表性成果獲獎(jiǎng)：

2013年國際硝酸鹽亞硝酸鹽生理及醫(yī)學(xué)大會(huì)摘要獎(jiǎng)；

2018年第一屆全國維康杯酸奶競賽二等獎(jiǎng)；

2018年國家級(jí)大學(xué)生創(chuàng)新創(chuàng)業(yè)項(xiàng)目獲批；

2019年省級(jí)大學(xué)生創(chuàng)新創(chuàng)業(yè)項(xiàng)目獲批；

2019年省級(jí)教研虛擬仿真項(xiàng)目獲批。

（3）代表性論文：

1. Fu H.; Deng W.; Yao L.; Gong M.; Lai S.; Liu J.; Li M.;, Xu H.; Wang J. * “Urinary NOx, a novel potential biomarker for autism spectrum disorder” Free Radical Biology & Medicine 2020, 146, 350. doi: 10.1016/j.freeradbiomed.2019.11.001. IF: 5.66.

2. Wang L.; Sparacino-Watkins CE.; Wang J.; Wajih N.; Varano P.; Xu Q.; Cecco E.; Tejero J.; Soleimani M.; Kim-Shapiro DB.; Gladwin MT. “Carbonic Anhydrase II Does Not Regulate Nitrite Dependent Nitric Oxide Formation and Vasodilation” British Journal of Pharmacology 2020, 177, 898. doi: 10.1111/bph.14887. IF: 6.81.

3. Liu L.; Ding C.; Tian M.; Yi D.; Wang J.; Zhao J.; Hu Y.; Wang C. “Fermentation improves the potentiality of capsicum in decreasing high-fat diet-induced obesity in C57BL/6 mice by modulating lipid metabolism and hormone response” Food Research International 2019, 24, 49-60. IF: 3.58.

4. Hu, C.; Zhang, H.; Zhang, M.; Mi, Z.; Wang, J.; Lu, W.; Su, J. “Identi?cation, Characterization and High-Performance Liquid Chromatography Quanti?cation for Process-Related Impurities in Abiraterone Acetate Bulk Drug” Journal of Chromatographic Science 2018, 1. IF: 1.22.

5. Wang, J. *; Keceli, G.; Cao, R.; Su. J.; Mi, Z. “Molybdenum-containing nitrite reductases: Spectroscopic characterization and redox mechanism” Redox Report 2017, 1, 17. IF: 1.96

6. Wang, J.; Krizowski, S.; Fischer, K; Niks, D.; Tejero, J.; Wang, L.; Sparacino-Watkins, C; Ragireddy, V.; Frizzell, S.; Kelley, E.E.; Zhang, Y.; Basu, P.; Hille, R.; Schwarz, G.; Gladwin, M.T. “Sulfite Oxidase Catalyzes Single-Electron Transfer at Molybdenum Domain to Reduce Nitrite to Nitric Oxide” Antioxidants & Redox Signaling 2015, 23, 283. IF: 5.83

7. Zhao, J.; Wang, J.; Yang, Y.; Lu, Y. “The Determination of Nitrate and Nitrite in Human Urine and Blood by High-Performance Liquid Chromatography and Cloud-Point Extraction” Journal of Chromatographic Science. 2015, 53, 1169. IF: 1.22

8. Zhao, J.; Lu, Y.; Fan, C.; Wang, J.; Yang, Y. “Development of a cloud point extraction and spectrophotometry-based microplate method for the determination of nitrite in human urine and blood” SAA 2015, 136, 802. IF: 2.93.

9. Liu C.; Wajih N.; Liu X.; Basu S.; Janes J.; Marvel M.; Keggi C.; Helms C.C.; Lee A.N.; Belanger A.M.; Diz D.I.; Laurienti P.; Caudell D.L.; Wang J.; Gladwin M.T.; Kim-Shapiro D.B. “Mechanisms of Human Erythrocytic Bioactivation of Nitrite” Journal of Biological Chemistry 2015, 290, 1281. IF: 4.11.

10. Sparacino-Watkins, C.; Tejero, J.; Sun, B.; Gauthier, M.C.; Thomas, J.; Ragireddy, V.; Merchant, B.A.; Wang, J.; Azarova, I.; Basu, P.; Gladwin, M.T. “Nitrite Reductase and NO Synthase Activity of the Mitochondrial Molybdopterin Enzyme mARC 1 and mARC 2” Journal of Biological Chemistry 2014, 289, 10345. IF: 4.11.

11. Zhao, X-J; Shiva, S.; Tejero, J.; Wang, J.; Frizzell, S.; Gladwin, M.T. “Mechanisms for Cellular NO Oxidation and Nitrite Formation in Lung Epithelial Cells” Free Radical Biology & Medicine 2013, 61,428. IF: 5.66.

12. Bueno, M.; Wang, J.; Mora A.L.; Gladwin, M.T. “Nitrite Signaling in Pulmonary Hypertension: Mechanisms of Bioactivation, Signaling and Therapeutics” Antioxidant & Redox Signaling 2013, 18, 1797. IF: 5.83.

13. Wang, J.; Schopfer, M. P.; Puiu, S. C.; Sarjeant, A. A. N.; Karlin, K. D. “Reductive Coupling of Nitrogen Monoxide (?NO) Facilitated by Heme/Copper Complexes” Inorganic Chemistry 2010, 49, 1404. IF: 4.85.

14. Schopfer, M. P.; Wang, J.; Karlin, K. D. “Bioinspired Heme, Heme/Nonheme Diiron, Heme/Copper, and Inorganic NOx Chemistry: ?NO(g) Oxidation, Peroxynitrite-Metal Chemistry, and ?NO(g) Reductive Coupling” Inorganic Chemistry 2010, 49, 6267. IF: 4.85.

15. Wang, J.; Schopfer, M. P.; Sarjeant, A. A. N.; Karlin, K. D. “Heme-Copper Assembly Mediated Reductive Coupling of Nitrogen Monoxide (?NO)” The Journal of American Chemical Society 2009, 131, 450. IF: 14.70.

16. Wen-Wen Deng; Yu Zong; Yu-Xiu Xiao*; Hexafluoroisopropanol-Based Deep Eutectic Solvent/Salt Aqueous Two-Phase Systems for Extraction of Anthraquinones from Rhei Radix et Rhizoma Samples, ACS Sustainable Chemistry & Engineering, 2017, 5: 4267-4275.

17. Wenwen Deng#; Long yu#; Xiao Li; Jia Chen; Xuanxuan Wang; Zixin Deng; Yuxiu Xiao*; Hexafluoroisopropanol-based hydrophobic deep eutectic solvents for dispersive liquid-liquid microextraction of pyrethroids in tea beverages and fruit juices, Food Chemistry, 2018, 274: 891-899.

18. Anqi Huang#; Wenwen Deng#; Dandan Wu; Shuwen Wu*; Yuxiu Xiao*; Hexafluoroisopropanol-salt aqueous two-phase system for extraction and purification of chlorogenic acid from ramie leaves, Journal of Chromatography A, 2019, 1597:196-201.

19. Ying Deng, Yonglong Pan, Meizhong Luo Detection and correction ofassembly errors ofrice Nipponbare reference sequence.Plant Biology 2014. 16: 643 - 650

（4）代表性專利：

肖玉秀，鄧文文; 一種小分子氟醇-鹽雙水相體系及其萃取方法，專利號(hào)：CN201710996118.8.

楊亞玲，趙嬌，寧金艷，王軍，呂云輝；一種血液中亞硝酸鹽的檢測方法，專利號(hào)：CN103760121 B

五、研究生畢業(yè)去向

1、碩士研究生：

推薦到省級(jí)事業(yè)單位、上市公司等院所、大型企業(yè)工作；推薦到國內(nèi)外著名高校讀博

六、聯(lián)系方式

聯(lián)系人：王軍

郵箱：jun_wang@hbut.edu.cn；2491549178@qq.com

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