QQWeiboFeedback 基于真實世界原則的電針與抗抑郁藥治療抑郁癥臨床效果評價研究 Alternative TitleClinical Study of Electro-acupuncture and Antidepressants on Depression Based on Ｒeal World Study Principle 張燁1; 楊昕婧1; 王思涵1; 馬學(xué)紅2; 魯雨荍2; 李晶3; 趙冰驄1; 圖婭1 First Author張燁 Correspondent Emailtuyab@263． Net Contribution Rank3 Abstract

目的:觀察電針與選擇性五羥色胺再攝取抑制劑類抗抑郁藥(SSRIs)治療抑郁癥的臨床效果及兩種干預(yù)措施的療效特點。方法:本研究基于真實世界研究(RWS)原則,納入60例抑郁癥患者,按患者意愿分為電針組(35例)和西藥組(25例),電針組選取百會、印堂作為主穴,隨證配穴,西藥組服用選擇性5-羥色胺再攝取抑制劑類藥物。治療8周,治療結(jié)束4周后隨訪。選用漢密爾頓抑郁量表(HAMD-24)和健康調(diào)查簡表(SF-36)在治療前后及隨訪時進行臨床評價。結(jié)果:治療8周后,電針組痊愈率為57.14%,西藥組為12%,2組痊愈率比較差異有統(tǒng)計學(xué)意義,治療后HAMD-24總評分差異有統(tǒng)計學(xué)意義。2種干預(yù)手段治療前后抑郁癥患者生存質(zhì)量總評分、生理職能、總體健康、精力、社會功能、情感職能、精神健康6個領(lǐng)域評分均差異有統(tǒng)計學(xué)意義,其中軀體疼痛、生理機能和總體健康狀況領(lǐng)域電針和西藥差異有統(tǒng)計學(xué)意義。結(jié)論:電針與SSRIs均能改善抑郁癥患者抑郁程度,提高抑郁癥患者的總體生存質(zhì)量,其中電針對軀體疼痛改善作用明顯,SSRIs對生理機能和總體健康狀況改善效果明顯。

Other Abstract

Abstract: Objective: To observe the clinical effectiveness and features of electro-acupuncture ( EA) and Selective Serotonin Ｒeuptake Inhibitors ( SSＲIs) on depression． Methods: Based on the Ｒeal World Study ( ＲWS) principle，60 participants who were diagnosed for depression were enrolled into an 8-week non-randomized controlled study and were divided into EA group ( n = 35) and SSＲIs group ( n = 25) according to their preference． The Hamilton Depression Ｒating Scale ( HAMD) and the MOS item short from health survey ( SF-36) were used to evaluate the depressive severity and quality of life ( QOL) respectively before and after treatment． Ｒesults: After 8 weeks intervention，there were significant differences between EA and SSＲIs groups in remission rate and the HAMD total score． There were also significant differences between the two groups in overall QOL，role-physical，general health，vitality，social functioning，roleemotional and mental health． In addition，EA and SSＲIs had significant difference with respect to bodily pain，physical functioning and general health． Conclusions: Both EA and SSＲIs intervention could improve depression and QOL． EA had advantage on improving bodily pain，and SSＲIs improved physical functioning better．

Keyword抑郁癥 真實世界研究 電針 生存質(zhì)量 2018-03-28 Language中文 Source Publication中國中醫(yī)基礎(chǔ)醫(yī)學(xué)雜志 ISSN1006-3250 Volume24Issue:03Pages:374-377Subtype期刊論文 Document Type期刊論文 Identifierhttp://ir.psych.ac.cn/handle/311026/27656 Collection中國科學(xué)院心理研究所
Corresponding Author張燁Affiliation1.北京中醫(yī)藥大學(xué)
2.北京中醫(yī)藥大學(xué)東方醫(yī)院
3.中國科學(xué)院心理研究所
Recommended Citation
GB/T 7714 張燁,楊昕婧,王思涵,等. 基于真實世界原則的電針與抗抑郁藥治療抑郁癥臨床效果評價研究[J]. 中國中醫(yī)基礎(chǔ)醫(yī)學(xué)雜志,2018,24(03):374-377. APA 張燁.,楊昕婧.,王思涵.,馬學(xué)紅.,魯雨荍.,...&圖婭.(2018).基于真實世界原則的電針與抗抑郁藥治療抑郁癥臨床效果評價研究.中國中醫(yī)基礎(chǔ)醫(yī)學(xué)雜志,24(03),374-377. MLA 張燁,et al."基于真實世界原則的電針與抗抑郁藥治療抑郁癥臨床效果評價研究".中國中醫(yī)基礎(chǔ)醫(yī)學(xué)雜志 24.03(2018):374-377. Files in This Item: File Name/Size DocType Version Access License 基于真實世界原則的電針與抗抑郁藥治療抑郁（228KB）期刊論文出版稿限制開放CC BY-NC-SAView Application Full Text Related ServicesRecommend this itemBookmarkUsage statisticsExport to EndnoteGoogle ScholarSimilar articles in Google Scholar[張燁]'s Articles[楊昕婧]'s Articles[王思涵]'s ArticlesBaidu academicSimilar articles in Baidu academic[張燁]'s Articles[楊昕婧]'s Articles[王思涵]'s ArticlesBing ScholarSimilar articles in Bing Scholar[張燁]'s Articles[楊昕婧]'s Articles[王思涵]'s ArticlesTerms of UseNo data!Social Bookmark/Share File name: 基于真實世界原則的電針與抗抑郁藥治療抑郁癥臨床效果評價研究.pdf Format: Adobe PDF

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