Randomized Controlled Trial

Actions

. 2012 Nov;67(11):1259-65.

doi: 10.1093/gerona/gls096. Epub 2012 Apr 10.

Affiliations

Randomized Controlled Trial

Effect of 12-week resistance exercise program on body composition, muscle strength, physical function, and glucose metabolism in healthy, insulin-resistant, and diabetic elderly Icelanders

O G Geirsdottir et al. J Gerontol A Biol Sci Med Sci. 2012 Nov.

Abstract

Background: Insulin is a stimulator of skeletal muscle protein anabolism and insulin resistance might therefore negatively affect muscle protein metabolism. We investigated muscle mass and physical function before and after a resistance exercise program in participants with prediabetes or type 2 diabetes mellitus (T2DM) in comparison to healthy controls.

Methods: This was a secondary analysis of a randomized controlled intervention designed to investigate resistance training among older adults. Glucose metabolism status was not a selection criteria for the trial, and group designation was done retrospectively. Participants (N = 237, 73.7 ± 5.7 y, 58.2% women) participated in a 12-week resistance exercise program (3 times/week; three sets, six to eight repetitions at 75%-80% of the one-repetition maximum), designed to increase strength and muscle mass of major muscle groups. Body composition, muscular strength, timed up and go test, 6-minute walk for distance, and blood chemical variables were measured at baseline and endpoint.

Results: Participants completing the study (n = 213) experienced significant changes in muscle strength or muscle function, which did not differ significantly between healthy (n = 198), prediabetic (n = 20), and T2DM participants (n = 17). Changes in serum glucose during the intervention differed by group: only glucose improved significantly in the prediabetic group, glucose and triacylglycerol improved significantly in the healthy group, whereas no serum parameter improved significantly in the T2DM group.

Conclusions: A 12-week resistance exercise program improves muscle strength and muscle function to a similar extent in healthy, prediabetic, and T2DM elderly people. However, according to our data, T2DM participants do not experience favorable changes in fasting glucose or HbA(1C).

Trial registration: ClinicalTrials.gov NCT01074879.

PubMed Disclaimer

Similar articles

Different types of resistance training in type 2 diabetes mellitus: effects on glycaemic control, muscle mass and strength.

Egger A, Niederseer D, Diem G, Finkenzeller T, Ledl-Kurkowski E, Forstner R, Pirich C, Patsch W, Weitgasser R, Niebauer J. Egger A, et al. Eur J Prev Cardiol. 2013 Dec;20(6):1051-60. doi: 10.1177/2047487312450132. Epub 2012 May 25. Eur J Prev Cardiol. 2013. PMID: 22637738 Clinical Trial.

Effect of exercise training on physical fitness in type II diabetes mellitus.

Larose J, Sigal RJ, Boulé NG, Wells GA, Prud'homme D, Fortier MS, Reid RD, Tulloch H, Coyle D, Phillips P, Jennings A, Khandwala F, Kenny GP. Larose J, et al. Med Sci Sports Exerc. 2010 Aug;42(8):1439-47. doi: 10.1249/MSS.0b013e3181d322dd. Med Sci Sports Exerc. 2010. PMID: 20639722 Clinical Trial.

Effects of whey proteins and carbohydrates on the efficacy of resistance training in elderly people: double blind, randomised controlled trial.

Arnarson A, Gudny Geirsdottir O, Ramel A, Briem K, Jonsson PV, Thorsdottir I. Arnarson A, et al. Eur J Clin Nutr. 2013 Aug;67(8):821-6. doi: 10.1038/ejcn.2013.40. Epub 2013 Mar 13. Eur J Clin Nutr. 2013. PMID: 23486511 Clinical Trial.

Muscle protein anabolism in type 2 diabetes.

Bassil MS, Gougeon R. Bassil MS, et al. Curr Opin Clin Nutr Metab Care. 2013 Jan;16(1):83-8. doi: 10.1097/MCO.0b013e32835a88ee. Curr Opin Clin Nutr Metab Care. 2013. PMID: 23196814 Review.

Cited by

Effect of Circuit Resistance Training on Glycemic Control of Females with Diabetes Type II.

Shabani R, Nazari M, Dalili S, Rad AH. Shabani R, et al. Int J Prev Med. 2015 Apr 10;6:34. doi: 10.4103/2008-7802.154923. eCollection 2015. Int J Prev Med. 2015. PMID: 25949784 Free PMC article.

Effects of resistance training on insulin sensitivity in the elderly: A meta-analysis of randomized controlled trials.

Jiahao L, Jiajin L, Yifan L. Jiahao L, et al. J Exerc Sci Fit. 2021 Oct;19(4):241-251. doi: 10.1016/j.jesf.2021.08.002. Epub 2021 Aug 19. J Exerc Sci Fit. 2021. PMID: 34552636 Free PMC article. Review.

Lean mass, grip strength and risk of type 2 diabetes: a bi-directional Mendelian randomisation study.

Yeung CHC, Au Yeung SL, Fong SSM, Schooling CM. Yeung CHC, et al. Diabetologia. 2019 May;62(5):789-799. doi: 10.1007/s00125-019-4826-0. Epub 2019 Feb 23. Diabetologia. 2019. PMID: 30798333

Effect of Rebound Exercises and Circuit Training on Complications Associated with Type 2 Diabetes: Protocol for a Randomized Controlled Trial.

Kaka B, Maharaj SS. Kaka B, et al. JMIR Res Protoc. 2018 May 7;7(5):e124. doi: 10.2196/resprot.8827. JMIR Res Protoc. 2018. PMID: 29735476 Free PMC article.

Nutrition in chronic pancreatitis.

Rasmussen HH, Irtun O, Olesen SS, Drewes AM, Holst M. Rasmussen HH, et al. World J Gastroenterol. 2013 Nov 14;19(42):7267-75. doi: 10.3748/wjg.v19.i42.7267. World J Gastroenterol. 2013. PMID: 24259957 Free PMC article. Review.

Publication types

Actions

Actions

Actions

MeSH terms

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Actions

Substances

Actions

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous

相關(guān)知識(shí)

Effect of Social Support on Psychological Well
The effect of stress on mental health
Effect of Health Education on Rehabilitation Outcome of Fracture Patients
The miraculous effect of lemon on health
Effect of individualized nutritional guidance during pregnancy and regu
Analysis of the Effect of Chronic Disease Management in Community on Standardized Medication in Patients with Hypertension
Effect of Medical Advice for Diet on Diabetes Self
The Study of the Effect of Family Support on Psychological Health in the Elderly Citizens
Effect of Early Psychological Intervention on Maternal Anxiety
Analysis on curative effect of applied behavioral analysis combined with structural teaching in treatment of childhood autism

網(wǎng)址: Effect of 12 http://www.u1s5d6.cn/newsview1646962.html