1.  近年發(fā)表的主要論文（*通訊作者）：

Publication list

ISI Researcher ID: http://www.researcherid.com/rid/K-8337-2016

Papers in ISI indexed journals

Year 2024

Qianlei Yang#; Ting Zhang#; Jian Liu#; Hui Lu; Chen Zhao; Chunchun Li; Koichi Kato; Dapeng Wang?*; Yan An?*. Sustained high expression of NRF2 inhibits cell apoptosis in arsenite-transformed human keratinocytes.Food and Chemical Toxicology.2024, 191:114875.

PMID: 39033872

        DOI: 10.1016/j.fct.2024.114875

Yuanhui Zhu#; Qianlei Yang;#; Jie Gu; Zhicheng Chen; Nan Jing; Tingxu Jin; Jiayuan Lin; Xin Wang; Jingwen Hu; Guixiang Ji?*; Yan An?*. ‘Environmental standard limit concentration’ arsenic exposure is associated with anxiety, depression and autism-like changes in early-life stage zebrafish. Journal of Hazardous Material. 2024,469:133953.(Top Journal)

PMID: 38461670

DOI: 10.1016/j.jhazmat.2024.133953

Tingxu Jin?#; Tongtong Huang#; Tianxue Zhang; Quan Li; Cheng Yan; Qian Wang; Xiufang Chen; Jing Zhou; Yitong Sun; Wenqing Bo; Ziqi Luo; Haodong Li; Yan An?*. A Bayesian Benchmark Concentration Analysis for Urinary Fluoride and Intelligence in Adults in Guizhou, China. Science of The Total Environment. 2024：171326.(Top Journal)

PMID: 38460703

DOI: 10.1016/j.scitotenv.2024.171326

Year 2023

Qianlei Yang#; Yan Rui#; Jie Zhang#; Ting Zhang Aojun Ye; Xinghua Qiao; Koichi Kato;Chang Chen?; Yan AN?. Reductive Stress Induced by NRF2/G6PD through Glucose Metabolic Reprogramming Promotes to Malignant Transformation in Arsenite-Exposed Human Keratinocytes. Science of The Total Environment. 2023，896: 165207.(Top Journal)

PMID: 37391132

       DOI: 10.1016/j.scitotenv.2023.165207

Rui Yan#; Jie Ding#；Xiaoyun Zhang; Tingxu Jin; Shudi Shi; Xirui Wang; Yu Zheng; Heran Li; Hengdong Zhang?;         

Yan AN?. Lead acetate induces cartilage defects and bone loss in zebrafish embryos by disrupting the GH/IGF-1  

       axis.Ecotoxicology and Environmental Safety.  2023, 253:114666.(Top Journal)

       PMID: 36812871

       DOI: 10.1016/j.ecoenv.2023.114666

Before 2022

Qianlei Yang #; Rui Yan #; Yuemei Mo#; Haixuan Xia; Hanyi Deng; Xiaojuan Wang; Chunchun Li; Koichi Kato; 

       Hengdong Zhang; Tingxu Jing?; Jie Zhang; Yan AN?.The Potential Key Role of the NRF2/NQO1 Pathway in   

       the Health Effects of Arsenic Pollution on SCC. International Journal of Environmental Research and Public 

       Health. 2022, 19(13): 8118.

PMID: 35805773

DOI: 10.3390/ijerph19138118

Rui Yan#; Jie Ding#; Yuanjie Wei; Qianlei Yang; Xiaoyun Zhang; Hairu Huang; Zhuoyue Shi; Yue Feng; Heran Li;     

       Hengdong Zhang; Wenjun Ding?; Yan AN?. Melatonin prevents NaAsO2-induced developmental cardio-

       toxicity in zebrafish through regulating oxidative stress and apoptosis. Antioxidants. 2022, 11(7): 1301.(Top Journal)

PMID: 35883792

DOI: 10.3390/antiox11071301

Jie Ding; Rui Yan; Luna Wang; Qianlei Yang; Xiaoyun Zhang; Nan Jing; Yuanjie Wei; Hengdong Zhang?; Yan AN?. Using Alizarin Red Staining to Detect Chemically Induced Bone Loss in Zebrafish Larvae. JoVE-Journal of Visualized Experiments.2021, 178: e63251.

PMID: 35037650

DOI: 10.3791/63251

Qi Kong#; Hanyi Deng#; Chunchun Li#; Xiaojuan Wang; Yasuyo Shimoda; Shasha Tao; Koichi Kato; Jie Zhang*; Kenzo Yamanaka*; Yan AN*. Sustained expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells. Science of The Total Environment. 2021, 756: 143840. (Top Journal)

         PMID: 33261869

DOI: 10.1016/j.scitotenv.2020.143840

Runa Wang#; Rui Yan#; Qianlei Yang; Heran Li; Jie Zhang; Yasuyo Shimoda; Koichi Kato; Kenzo Yamanaka*; Yan AN*. Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos. Ecotoxicology and Environmental Safety. 2020, 201: 110820. (Top Journal)

PMID: 32531574

DOI: 10.1016/j.ecoenv.2020.110820

Jiaoyuan Mao#; Qianlei Yang#; Makoto Miyazawa; Motofumi Miura; Luna Wanga; Haixuan Xiaa; Koichi Kato; Kenzo Yamanaka*; Yan AN*. Possible differences in the mechanism of malignant transformation of HaCaT cells by arsenite and its dimethyl metabolites, particularly dimethylthioarsenics. Journal of Trace Elements in Medicine and Biology. 2020, 61: 126544. 

PMID: 32416464

DOI: 10.1016/j.jtemb.2020.126544

Jing wu#; Yiping Ni#; Qianlei Yang#; Jiayuan Mao; Yasuyo Shimoda; Xuerui Zhu; Luna Wang; Haixuan Xia; Shasha Tao; Koichi Kato; Jie Zhang; Dapeng Wang*; Kenzo Yamanaka*; Yan AN*. Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes. Science of The Total Environment. 2020, 734: 139425. (Top Journal)

PMID: 32450402

DOI: 10.1016/j.scitotenv.2020.139425

Jing Wu#, Jie Zhang#, Jihua Nie#, Junchao Duan, Yanfeng Shi, Lin Feng, Xiaozhe Yang, Yan AN*, Zhiwei Sun*. The chronic effect of amorphous silica nanoparticles and benzo[a]pyrene co-exposure at low dose in human bronchial epithelial BEAS-2B cells. Toxicology Research. 2019, 8(5):731-740. 

PMID: 31588350

DOI: 10.1039/c9tx00112c

Qianlei Yang#; Hanyi Deng#; Haixuan Xia#; Mengchuan Xu; Guotao Pan; Jiayuan Mao; Shasha Tao; Kenzo Yamanaka*; Yan AN*. High Nrf2 expression predicted poor prognosis in patients with lung cancer: A meta-analysis of cohort studies. Free Radical Research. 2019, 1-9. 

PMID: 31298052

DOI:10.1080/10715762.2019.1642472

Qianlei Yang#; Zhen Zhu#; Luna Wang; Haixuan Xia; Xiaojuan Wang; Jing Wu; Koichi Kato; Heran Li; Jie Zhang*; Kenzo Yamanaka*; Yan AN*. The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells. Environmental Toxicology and Pharmacology. 2019, 69:66-71.

PMID: 30959417

DOI:10.1016/j.etap.2019.04.001

Jing wu; Yiping Ni; Xiaojuan Wang; Qianlei Yang;Jiayuan Mao; Jian Tong; Jie Zhang*; Yan AN*. Role of mitochondrial DNA in oxidative damage induced by sodium arsenite in human bronchial epithelial cells. Journal of Toxicology and Environmental Health-part A.2019,82(18):990-996.

PMID: 31679505

DOI:10.1080/15287394.2019.1686108.

Jiting Liu; Li Zhang; Lixia Feng; Ming Xu; Yue Gao; Peng Zhou; Zhengmin Yu; Baoli Zhu; Yan AN*; Hengdong Zhang*. Association Between Single Nucleotide Polymorphism (rs4252424) in TRPV5 Calcium Channel Gene and Lead Poisoning in Chinese Workers. Molecular Genetics & Genomic Medicine. 2019; e562. https://doi. org/10.1002/mgg3.562 .

Hengdong Zhang, Ming Xu, Qiuni Zhao, Kai Sun,Wei Gong, Qiaoyun Zhang, Baoli Zhu, Yan An*. Association between   Polymorphism of Exportin-5 andSusceptibility to Lead Poisoning in a Chinese Population. International Journal of   Environmental Research and Public Health.2017, 14, 36.

  DOI:10.3390/ijerph14010036

Dapeng Wang; Yasuyo Shimoda; Sanxiang Wang;Zhenghui Wang; Jian Liu; Xing Liu; Huanyu Jin; Fenfang Gao; Jian Tong;   KenzoYamanaka; Jie Zhang*; Yan An*. Total Arsenic andSpeciation Analysis of Saliva and Urine Samples from   Individuals Living inChronic Arsenicosis Area in China. EnvironmentalHealth and Preventive Medicine. 2017,22:45.

  DOI:10.1186/s12199-017-0652-5

Xing Liu; Bin Sun;Xiaojuan Wang; Jihua Nie; Zhihai Chen; Yan AN*; Jian Tong*. Synergistic Effect of Radon       and SodiumArsenite on DNA   Damage in HBE Cells. EnvironmentalToxicology and Pharmacology. 2016,41: 127-131.

DOI:10.1016/j.etap.2015.11.013

Dapeng Wang; Yuan Ma; XuYang; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; ChunchunLi; Fenfang Gao; Jian Tong; Kenzo Yamanaka;Yan AN*. Hypermethylation of Keap1 Gene Inactivates Its Functionand Promotes Nrf2 Nuclear Accumulation Is Involved in Arsenite-Induced HumanKeratinocyte Transformation. Free RadicalBiology and Medicine. 2015, 89:209-219.(Top Journal)

DOI：10.1016/j.freeradbiomed.2015.07.153

Xu Yang, Dapeng Wang, Yuan Ma, Xiguo Xu, Yingying Zhao, Zhen Zhu, Xiaojuan Wang, Hanyi Deng, ChunchunLi, Fenfang Gao, Jian Tong, Kenzo Yamanaka, Yan AN*. Continuous Activation of Nrf2 and Its Target AntioxidantEnzymes Leads to Arsenite-Induced Malignant Transformation of Human BronchialEpithelial Cells. Toxicology and AppliedPharmacology. 2015, 289:231-239. (Top Journal)

DOI:10.1016/j.taap.2015.09.020

Huanyu Jin, Hua Yin,Yan AN*. The effect of gamma ray on thethermo-mechanical property of silk fibroin. ThermalScience. 2013, 17(5): 1521-1522.

DOI: 102298/TSCI1305521J

Yan AN*, Koichi Kato , Masayuki Nakano, Hiroshi Otsu, Shoji Okada, Kenzo Yamanaka*. Specific induction of oxidative stress in terminal bronchiolar Clara cellsduring dimethylarsenic-induced lung tumor promoting process in mice. Cancer Letters.2005,230(1): 57-64.(Top Journal)

DOI:10.1016/j.canlet.2004.12.029

Yan AN*, Zenglin Gao, Zhongwen Wang, Shaohe Yang, Jianfen Liang, Yan Feng, Koichi Kato,Masayuki Nakano, Shoji Okada, Kenzo Yamanaka*. Immunohistochemical analysis ofoxidative DNA damage in arsenic-related human skin samples fromarsenic-contaminated area of China. CancerLetters. 2004, 214(1): 11-18.(Top Journal)

DOI:10.1016/j.canlet.2004.04.005

2.  專利

發(fā)明專利

【1】Dimethylarsinous acid-induced Malignantly Transformed Cell Line of Human Keratinocytes and Use thereof. 【PCT/CN2021/088303】【US 20230314407 A1】

【2】Dimethylmonothioarsinic acid-induced Malignantly Transformed Cell Line of Human Keratinocytes and Use thereof. 【PCT/CN2021/077088】【US 2023-0159910 A1】

【3】一種線粒體自噬抑制劑在制備治療砷至細胞惡性轉化的疾病藥物中的應用【ZL2022107802224】

【4】硫代二甲基胂酸致人角質形成細胞惡性轉化細胞模型及其構建【ZL2021101095403】

【5】二甲基亞胂酸致人角質形成細胞惡性轉化細胞模型及其構建【ZL2021103053231】 

實用新型專利

【1】條帶切割裝置【ZL2018201134810】.

【2】一種用于涂覆蛋白條帶的盒【ZL2018201299739】

【3】一種牙刷【ZL2018217130627】

【4】用于細胞培養(yǎng)的凍存盒【ZL2019210013294】

【5】轉盤式試管架【ZL2019210004789】

【6】一種變容式洗碗機【ZL2019218943380】

【7】一種便于清洗的榨汁杯【ZL2019218945259】

【8】一種衣物脫水擰干裝置【ZL2019218655379】

【9】一種化學藥品輔助稱量裝置 【ZL202020770757X】

【10】一種密封性好的制膠裝置 【ZL2020203907933】

【11】一種滅菌指示帶切割器 【ZL2020206768928】

【12】夾閉式滅菌指示帶切割器 【ZL2020206786485】

【13】一種易于批量清洗移液管的轉換器【ZL2020208994247】

【14】一種簡易小鼠糞尿分離及收集裝置【ZL2020207334485】

【15】一種腳踩式酒精噴壺【ZL2020207715491】

【16】一種western blot抗體洗脫裝置【ZL2021203206533】

【17】攪拌器【ZL2021205452710】

【18】一種溢流自清潔養(yǎng)殖缸【ZL2021207446343】

【19】一種便于使用的手指型指甲銼【ZL2021208273727】

【20】蛋白質提取冰盒【ZL2021213007220】

【21】一種斑馬魚胚胎和幼魚的觀察裝置【ZL2021221124917】

【22】一種基于戶外出行的晴雨傘背包【ZL2021222911483】

【23】一種細胞劃痕實驗裝置【ZL202122516354X】

【24】一種斑馬幼魚心臟解剖用鑷子刀【ZL202122454929X】

【25】可折疊干果處理裝置）【2021226100726】

【26】一種微量離心管開蓋器【ZL202220498263X】

【27】一種平板保護套【ZL2022207041411】

【28】一種基于凍存管的運輸裝置【ZL2022208332984】

【29】一種96孔板加樣裝置【ZL2022216802106】

【30】一種醫(yī)用組織鑷【ZL2022222346488】

【31】一種switch游戲機保護套【ZL2022224013361】

【32】一種新型核酸提取用過濾裝置【ZL2022231335497】

【33】一種細胞培養(yǎng)用傳代裝置【ZL2023202030970】

【34】PVDF膜自定義尺寸裁剪裝置【ZL2023202094703】

【35】一種細胞運輸容器保護裝置【ZL2023206320582】

【36】一種多功能細胞培養(yǎng)液存取裝置【ZL2023202129933】

【37】一種可循環(huán)使用的光敏性離心管避光套【ZL2023207335316】

【38】一種離心后細胞重懸儀器【ZL2023203671572】

【39】一種用于Western blot實驗的切膜裝置【ZL2023205990750】

【40】一種細胞侵襲實驗用Transwell小室【ZL2023203819724】

【41】一種斑馬魚卵的篩選裝置【ZL2023211892350】

【42】一種用于細胞提取的細胞刷【ZL2023204281808】

【43】一種易于分離上清液的EP管【ZL2023205007849】

【44】一種免疫熒光實驗用六孔板裝置【ZL20232050079】

【45】一種細胞實驗光照箱【ZL2023204094214】

【46】一種細胞實驗用培養(yǎng)裝置【ZL2024218878359】

3. 主（參）編著作

[1] 參編：《環(huán)境毒理學基礎》，人民衛(wèi)生出版社，2024年6月 第四版（ISBN 978-7-04-062198-3）.  

[2] 參編：《環(huán)境毒理學基礎》，人民衛(wèi)生出版社，2018年11月 第三版（ISBN 978-7-04-050623-5）. 

[3] 參編：《毒理學基礎》，人民衛(wèi)生出版社，2017年8月 第七版（ISBN 978-7-117-24633-0）. 

[4] 參編：《現代環(huán)境毒理學》，中國環(huán)境出版社，2015年12月 第一版（ISBN 978-7-5111-2381-7 ）. 

[5] 參編:   《毒理學試驗方法與技術》，人民衛(wèi)生出版社，2018年3月 第四版（ISBN 978-7-117-27879-9）

[6]主編：《國家污染物環(huán)境健康風險名錄.生物分冊》，中國環(huán)境出版社，2013年12月 第一次印刷（36萬字，  ISBN 978-7-5111-1678-9）. 

相關知識

蘭州大學公共衛(wèi)生學院
杭州師范大學公共衛(wèi)生學院
健康與公共衛(wèi)生學院
公共衛(wèi)生與預防醫(yī)學學科簡介
廣東潮州衛(wèi)生健康職業(yè)學院
蘇州薇琳美容醫(yī)院
蘇州治療皮膚病好的醫(yī)院排名
【顧雪平】蘇州市康復醫(yī)院
蘇州九龍醫(yī)院產檢流程
公共健康學院開展2018年預防醫(yī)學座談會

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