首頁資訊茶多酚防治2型糖尿病的分子機理研究進展

茶多酚防治2型糖尿病的分子機理研究進展

來源：泰然健康網(wǎng) 時間：2024年12月15日 17:08

摘要： 茶多酚作為天然功能性物質(zhì)能有效防治2型糖尿病,但是其具體作用機制仍不太清楚。研究表明它的作用機理主要是通過調(diào)控糖代謝平衡：包括降低α-糖苷酶、α-淀粉酶等雙糖酶活性,調(diào)控胰島素信號傳導途徑及AMPK途徑中多個分子靶點的磷酸化水平,影響酶與轉(zhuǎn)錄因子的活性與表達,減弱胰島素抵抗及糖異生作用,促進胰島素的合成與分泌,促進靶組織對葡萄糖的吸收與利用等;同時,茶多酚能夠調(diào)控脂代謝,通過抑制脂質(zhì)合成與積累的相關(guān)酶的活性及轉(zhuǎn)錄因子的表達,促進脂質(zhì)的氧化代謝,減輕脂代謝紊亂;另外,茶多酚的抗氧化與抗炎作用可以有效減輕組織細胞的氧化傷害和炎癥損傷,減少細胞凋亡。

關(guān)鍵詞: 茶多酚, EGCG, 2型糖尿病, 分子機理

Abstract: As natural functional materials, tea polyphenols have been shown to effectively prevent the development of type 2 diabetes mellitus (T2DM), but the mechanism of action is still unclear. For further study, this article summarizes the molecular mechanisms implicated in the beneficial metabolic effects of tea polyphenols. In the respect of glycometabolism, tea polyphenols significantly reduce the absorption of simple sugars by inhibiting disaccharidases (α-amylase and α-glucosidase). Then, tea polyphenols can ameliorate insulin resistance and inhibit gluconeogenesis via insulin signaling and AMPK pathway, including regulation of the phosphorylation and expression of protein kinases, and relevant transcription factors. In addition, tea polyphenols stimulate glucose uptake and utilization by increasing insulin secretion. Meanwhile, tea polyphenols showed great effects on improving lipid metabolic disorder by suppressing lipid synthesis and accumulating the activity of related enzyme and the expression of transcription factors as well as stimulating the oxidative metabolism of fat and lipid and suppressing the lipidosis. Moreover, tea polyphenols showed antioxidative and anti-inflammatory capability to ameliorate cell damage and apoptosis induced by oxidation and inflammation.

Key words: tea polyphenols, EGCG, type 2 diabetes mellitus, molecular mechanism

中圖分類號:

Q946.84+1

R587.1

網(wǎng)址: 茶多酚防治2型糖尿病的分子機理研究進展 http://www.u1s5d6.cn/newsview548559.html