基本信息：

姓       名：盧言慧

畢業(yè)院校 ：首都醫(yī)科大學(xué)  

學(xué)       歷：博士研究生

專       業(yè)：營養(yǎng)與食品衛(wèi)生學(xué)博士；護(hù)理學(xué)博士后

所屬教研室：內(nèi)外科護(hù)理學(xué)教研室

職稱/職務(wù)：研究員，碩/博士生導(dǎo)師，博士后合作導(dǎo)師

電       話：010-82805228

郵       箱：luyanhui@bjmu.edu.cn

科研項目：

2025-01至2028-12國家自然科學(xué)基金（面上項目）：腸道Akk菌源性維生素B12通過調(diào)控神經(jīng)細(xì)胞重編程改善糖尿病認(rèn)知障礙的作用及機制，主持，在研。

2021-01至2023-12國家自然科學(xué)基金（青年項目）：Akk菌通過調(diào)控NLRP3炎癥小體改善2型糖尿病所致認(rèn)知功能障礙的作用及其機制，主持，已結(jié)題。

2018-05至2021-01博士后課題基金一等資助：核糖糖基化對2型糖尿病患者認(rèn)知功能的影響及機制研究，主持，已結(jié)題。

2019-01至2020.12北京市自然基金（青年項目）：腸道菌群代謝產(chǎn)物短鏈脂肪酸在2型糖尿病所致認(rèn)知功能障礙中的作用及機制研究，主持，已結(jié)題。

2023-01至2023-12北京大學(xué)臨床醫(yī)學(xué)+X青年專項：腸道菌群代謝物乙酸通過泛素化-線粒體自噬途徑調(diào)控NLRP3炎癥小體改善糖尿病認(rèn)知功能障礙機制研究，主持，已結(jié)題。

2024-01至2026-12國家自然科學(xué)基金（集成項目）：腸道菌群對代謝性疾病的調(diào)控作用與干預(yù)策略研究，骨干，在研。

2022-12至2027-12科技部“干細(xì)胞研究與器官修復(fù)”重點專項項目：母胎耐受機制及其在干細(xì)胞移植免疫耐受誘導(dǎo)中的應(yīng)用，骨干，在研。

發(fā)表文章：

1.Chunyou Mao#*, Mengru Gao#, Shaokun Zang#, Yanqing Zhu#, Dandan Shen, Linan Chen, Liu Yang, Zhiwei Wang, Huibing Zhang, Weiwei Wang, Qingya Shen, Yanhui Lu*, Xin Ma*, Yan Zhang*. Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nature Communications. 2023 Nov 22;14(1):7620. (Q1, IF: 14.7)

2. Lin Wen, Yanhui Lu*, Xin Li, Yu An, Xiao Tan, Liangkai Chen*. Association of frailty and pre-frailty with all-cause and cardiovascular mortality in diabetes: Three prospective cohorts and a meta-analysis. Ageing Res Rev. 2025 Apr;106:102696. (Q1, IF=12.5)

3. Jie Zheng#, Yu An#, Yage Du, Ying Song, Qian Zhao, Yanhui Lu*. Effects of short-chain fatty acids on blood glucose and lipid levels in mouse models of diabetes mellitus: a systematic review and network meta-analysis. Pharmacological Research. 2024 Jan;199:107041. (Q1, IF: 9.1)

4. Tingjing Zhang#, Yu An#, Zhenfei Shen, Honghao Yang, Jinguo Jiang, Liangkai Chen, Yanhui Lu*, Yang Xia*. Serum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank. Alzheimer's research & therapy. 2024 May 11;16(1):106. (Q1, IF: 7.9)

5.Yanhui Lu, Hua Jiang, Huijing Zhang, Ruxue Li, Qi Zhang, Dan Luo, Xue Cai, Mingzi Li*. Serum oxidized low density lipoprotein serves as a mediator for the inverse relationship between serum D-ribose and cognitive performance in type 2 diabetic patients. Free Radical Biology and Medicine. 2021 Aug 1;171:91-98. (Q1, IF: 7.1)

6.Limin Cao#, Yu An#, Huiyuan Liu, Jinguo Jiang, Wenqi Liu, Yuhan Zhou, Mengyuan Shi, Wei Dai, Yanling Lv, Yuhong Zhao, Yanhui Lu*, Liangkai Chen*, Yang Xia*. Global epidemiology of type 2 diabetes in patients with NAFLD or MAFLD: a systematic review and meta-analysis. BMC Medicine. 2024, 22:101. (Q1, IF: 7.0)

7.Tingjing Zhang#, Jiangen Song#, Zhenfei Shen, Kewan Yin, Feifei Yang, Honghao Yang, Zheng Ma, Liangkai Chen, Yanhui Lu*, Yang Xia*. Associations between different coffee types, neurodegenerative diseases, and related mortality: findings from a large prospective cohort study. The American journal of clinical nutrition. 2024 Aug 19:S0002-9165(24)00671-3. (Q1, IF: 6.5)

8. Xin Zhang#, Tianzhi Xie#, Shuang Zhou#, Yingxuan Yuan, Weixuan Chen, Jie Zheng, Xuebo Liu, Tian Yuan*, Yanhui Lu*, Zhigang Liu*. Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids. Food & Function. 2024 Feb 19;15(4):2249-2264. (Q1, IF: 5.1)

9. Zhaoming Cao, Yu An, Yanhui Lu*. Altered N6-methyladenosine modification patterns and transcript profiles contributes to cognitive dysfunction in high-fat induced diabetic mice. International Journal of Molecular Sciences. 2024 Feb 6;25(4):1990. (Q1, IF: 4.9)

10. Yu An#, Zhaoming Cao#, Yage Du, Guangyi Xu, Jingya Wang, Jie Zheng, Yanhui Lu*. Bidirectional two-sample, two-step mendelian randomisation study reveals mediating role for gut microbiota between vitamin B supplementation and Alzheimer’s disease. Nutrients. 2024 Nov 18;16(22):3929. (Q1, IF:4.8)

11.Ying Song#, Fangxiao Cheng#, Yage Du, Jie Zheng, Yu An, Yanhui Lu*. Higher adherence to the AMED, DASH, and CHFP dietary patterns is associated with better cognition among Chinese middle-aged and elderly adults. Nutrients. 2023 Sep 15(18), 3974. (Q1, IF: 4.8)

12. Yage Du#, Yu An#, Ying Song, Nan Li, Jie Zheng, Yanhui Lu*. Live and pasteurized Akkermansia muciniphila ameliorates diabetic cognitive impairment by modulating gut microbiota and metabolites in db/db mice. Experimental Neurology. 2024 May 21:114823. (Q1, IF:4.6)

13.Ying Song#, Yage Du#, Yu An, Jie Zheng, Yanhui Lu*. A systematic review and meta-analysis of cognitive and behavioral tests in rodents treated with different doses of D-ribose. Frontiers in Aging Neuroscience. 2022 Nov 9; 14:1036315. (Q2, IF: 4.1)

14.Yanhui Lu, Xinjun Jiang,Shuling Liu,Mingzi Li*. Changes in cerebrospinal fluid Tau and β-Amyloid levels in diabetic and prediabetic patients: a meta-analysis. Frontiers in Aging Neuroscience. 2018 Oct 11;10:271. (Q2, IF: 4.1)

15.Yage Du, Xiaoying Li, Yu An, Ying Song, Yanhui Lu*. Association of gut microbiota with sort-chain fatty acids and inflammatory cytokines in diabetic patients with cognitive impairment: A cross-sectional, non-controlled study. Frontiers in Nutrition. 2022 Jul 22; 9:930626. (Q2, IF: 4.0)

16. Yage Du, Liuqing Yang, Yu An, Ying Song, Yanhui Lu*. Health-related quality of life and associated factors in elderly individuals with dyslipidemia in rural Northern China. Quality of Life Research. 2023 Dec;32(12):3547-3555. (Q1, IF: 3.3)

17.Yanhui Lu, Yu An, Huanling Yu, Fengyuan Che, Xiaona Zhang, Hongguo Rong, Rong Xiao*. Sex-specific nonlinear associations between serum lipids and different domains of cognitive function in middle to older age individuals. Metabolic Brain Disease. 2017 Aug;32(4):1089-1097. (Q2, IF: 3.2)

18.Yanhui Lu, Pengbo Xing, Xue Cai, Dan Luo, Ruxue Li, Cathy Lloyd, Norman Sartorius, Mingzi Li*. Prevalence and risk factors for diabetic peripheral neuropathy in type 2 diabetes in 14 countries: the INTERPRET-DD study. Frontiers in Public Health. 2020 Oct 20;8:534372. (Q2, IF: 3.0)

19.Zhaoming Cao*, Yage Du, Guangyi Xu, He Zhu, Yinchao Ma, Ziyuan Wang, Shaoying Wang, Yanhui Lu*. From diabetes to dementia: identifying key genes in the progression of cognitive impairment. Brain Sciences. 2024;14(10):1035. (Q3, IF:2.7)

20.Yanhui Lu, Yu An, Jin Guo, Xiaona Zhang, Hui Wang, Hongguo Rong, Rong Xiao1*. Dietary intake of nutrients and lifestyle affect the risk of mild cognitive impairment in the Chinese elderly population: a cross-sectional study. Frontiers in Behavioural Neuroscience. 2016 Nov 29;10:229. (Q2, IF: 2.6)      

21. Yage Du#, Qi Zhang#, Xiaolan Zhang, Ying Song, Jie Zheng, Yu An*, Yanhui Lu*. Correlation between inflammatory biomarkers, cognitive function and glycemic and lipid profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Clinical Biochemistry. 2023 Nov; 121-122:110683. (Q2, IF: 2.5)

22. Yanhui Lu, Yu An, Chenyan Lv, Weiwei Ma, Yuandi Xi, Rong Xiao*. Dietary soybean isoflavones in Alzheimer’s disease prevention. Asia Pacific Journal of Clinical Nutrition. 2018;27(5):946-954. (Q4, IF: 1.3)

23.Jie Zheng#, Fangxiao Cheng#, Yage Du, Ying Song, Zhaoming Cao, Mingzi Li, Yanhui Lu*. Metabolic signatures and potential biomarkers in the progression of type 2 diabetes mellitus with cognitive impairment patients: A cross-sectional study. Interdisciplinary Nursing Research. 2023 February 2(1):p 19-26.

所獲獎項：

2024年   北京市優(yōu)秀農(nóng)工黨員

2019-09 北京大學(xué)軍訓(xùn)嘉獎令

2018-12 北京大學(xué)護(hù)理學(xué)院青年教師比賽一等獎

社會兼職：

國家自然基金委項目評審專家

教育部學(xué)位論文評審專家

云南省科技戰(zhàn)略(評審)專家

Nursing Communication雜志主編

中華行為醫(yī)學(xué)與腦科學(xué)雜志編委

中華糖尿病雜志編委

《中國醫(yī)藥生物技術(shù)》雜志第三屆編委會常務(wù)編委

中西醫(yī)結(jié)合護(hù)理雜志(中英文)編委

北美華人營養(yǎng)學(xué)會會員

中國營養(yǎng)學(xué)會營養(yǎng)與免疫分會第一屆委員會委員

中國營養(yǎng)學(xué)會特殊營養(yǎng)分會第五屆委員會委員

中國健康管理協(xié)會護(hù)理分會第一屆理事會常務(wù)理事

北京市護(hù)理學(xué)會護(hù)理管理專業(yè)委員會委員

北京大學(xué)護(hù)理學(xué)院學(xué)位評定分委員會委員

International Journal of Surgery審稿人

Obesity Reviews審稿人

Food&Function審稿人

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