酮體代謝與阿爾茨海默病

作者單位:

西安交通大學,西安交通大學,西安交通大學

基金項目:

國家自然科學基金(31070740，31370844)，中央高?；究蒲袠I(yè)務(wù)費專項資金(08143008，08143101)資助項目

Ketone Bodies Metabolism and Alzheimer′s Disease

Author:

SHI Le

Center of Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi′an Jiaotong University, Xi′an 710049, China
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LONG Jian-Gang

Center of Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi′an Jiaotong University, Xi′an 710049, China
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LIU Jian-Kang

Center of Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi′an Jiaotong University, Xi′an 710049, China
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Affiliation:

XI'AN JIAOTONG UNIVERSITY,XI'AN JIAOTONG UNIVERSITY,XI'AN JIAOTONG UNIVERSITY

Fund Project:

This work was supported by grants from The National Natural Science Foundation of China (31070740, 31370844), the Fundamental Research Funds for the Central Universities (08143008, 08143101)

摘要:

阿爾茨海默病(Alzheimer's disease，AD)是老年癡呆癥的一種主要類型，也是神經(jīng)退行性疾病中發(fā)病率最高的一種疾?。S著我國老齡人口的持續(xù)上升，AD患者人數(shù)也呈增長趨勢．研究表明，腦內(nèi)葡萄糖代謝的降低遠早于β淀粉樣沉淀發(fā)生，而酮體是腦內(nèi)替代葡萄糖的主要能量來源．因此，腦中能量代謝底物轉(zhuǎn)換為酮體是AD早期代謝特征．目前，AD病理進程中酮體調(diào)控的機制還不清楚．深入了解AD發(fā)生、發(fā)展過程中酮體代謝的分子機制，對于尋找AD早期診斷標志物、探索AD的防治方法具有重要意義．本文就酮體代謝及其在AD中的研究進展進行綜述．

Abstract:

Alzheimer's disease (AD) is the most common type of dementia, and has the highest incidence rate in neurodegenerative disorders. As the aged population robustly arises in China, the number of patients with AD is increasing accordingly. Studies show that decline in glucose metabolism occurs prior to amyloid deposits, and ketone bodies are the main alternative substrates for glucose in brain. Thus, the bioenergetic shift to ketone bodies is a characteristic of AD at early stage. At present, the mechanism of regulation of ketone bodies metabolism in AD pathogenesis is still unknown. In-depth understanding of ketone bodies metabolism involved in the occurrence and process of AD will lay a foundation in looking for new markers in early diagnosis and exploring prevention strategy of AD. Here we review AD-related ketone bodies metabolism and its research progress.

時樂,龍建綱,劉健康.酮體代謝與阿爾茨海默病[J].生物化學與生物物理進展,2015,42(4):323-328

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