教育背景

博士 2015.09-2019.06 中國科學院大學 微生物

碩士 2009.11-2011.11 荷蘭瓦赫寧根大學 食品安全

學士 2005.09–2009.06 中國農(nóng)業(yè)大學 食品質(zhì)量與安全

工作經(jīng)歷

起止時間 單位名稱 專業(yè)技術職務

2025.01-至今 山東大學微生物改造技術研究院/全國重點實驗室 教授

2022.08-2024.12 山東大學微生物技術研究院/國家重點實驗室 研究員

2012.02-2022.07 中國科學院微生物研究所微生物資源前期開發(fā)國家重點實驗室 助理實驗師、助理研究員、副研究員

研究方向

1.腸道微生物培養(yǎng)組學

2.腸道新功能菌株發(fā)掘與機制研究

科研項目

1.2025.01-2027.12國家自然科學基金委優(yōu)秀青年基金項目“腸道微生物培養(yǎng)、功能與機制研究”，200萬元

2.2023.01-2025.12山東省泰山學者青年專家項目，75萬

3.2024.01-2026.12山東省優(yōu)青項目“腸道微生物資源收集及功能機制研究”，50萬

4.2022.01-2025.12國家自然科學基金面上項目“一株產(chǎn)新型細菌素腸球菌的抑菌機理及潛在應用的基礎研究”，58萬元

5.2022.01-2026.12國家重點研發(fā)計劃“變革性技術關鍵科學問題”專項、“高通量培養(yǎng)篩選鑒定健康相關微生物的關鍵技術”項目、“微生物高通量培養(yǎng)與表征”課題，105萬元

6.2020.02-2024.12國家重點研發(fā)計劃“合成生物學”專項、“合成生物腸道菌群體系構建及應用”項目、“重要腸道微生物的合成生物學設計與功能強化”課題，118.4萬元

7.2022.12-2027.11國家重點研發(fā)計劃“生物大分子與微生物組”專項、“微生物組學新技術及相關實驗動物體系”項目、“菌群功能模塊定向培養(yǎng)和理性調(diào)控技術”課題，231萬元

8.2017.01-2019.12中科院重點部署項目，人體與環(huán)境健康的微生物組共性技術研究項目“非人靈長類實驗動物模型腸道微生物菌株資源庫的構建”課題，102萬元

代表性論文

(1)Liu, Chang; Du, Meng-Xuan; Xie, Li-Sheng; Wang, Wen-Zhao; Chen, Bao-Song; Yun, Chu-Yu; Sun, Xin-Wei; Luo, Xi; Jiang, Yu; Wang, Kai; Jiang, Min-Zhi; Qiao, Shan-Shan; Sun, Min; Cui, Bao-Juan; Huang, Hao-Jie; Qu, Shu-Ping; Jiang, Min-Zhi; Wu, Dalei; Wang, Lu-Shan; Jiang, Changtao*; Liu, Hong-Wei*; Liu, Shuang-Jiang*; Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids, NATURE MICROBIOLOGY, 2024;9(2):434-450

(2)Liu, Chang; Zhou, Nan; Du, Meng-Xuan; Sun, Yu-Tong; Wang, Kai; Wang, Yu-Jing; Li, Dan- Hua; Yu, Hai-Ying; Song, Yuqin; Bai, Bing-Bing; Xin, Yuhua; Wu, Linhuan; Jiang, Cheng-Ying; Feng, Jie; Xiang, Hua; Zhou, Yuguang; Ma, Juncai; Wang, Jun; Liu, Hong-Wei*; Liu, Shuang-Jiang*; The Mouse Gut Microbial Biobank expands the coverage of cultured bacteria, NATURE COMMUNICATIONS, 2020, 11(1): 79

(3)Liu, Chang#*; Du, Meng-Xuan#; Abuduaini, Rexiding#; Yu, Hai-Ying; Li, Dan-Hua; Wang, Yu-Jing; Zhou, Nan; Jiang, Min-Zhi; Niu, Peng-Xia; Han, Shan-Shan; Chen, Hong-He; Shi, Wen-Yu; Wu, Linhuan; Xin, Yu-Hua; Ma, Juncai; Zhou, Yuguang; Jiang, Cheng-Ying; Liu, Hong-Wei; Liu, Shuang- Jiang*; Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank, MICROBIOME, 2021, 9(1): 119

(4)Qiao, Shan-Shan#;Liu, Chang#; Sun, Li; Wang, Tao; Dai, Huan-Qin; Wang, Kai; Bao, Li; Li, Han-Tian; Wang, Wen-Zhao; Liu, Shuang-Jiang*; Liu, Hong-Wei*; Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism, Nature Metabolism, 2022, 4(10): 1271-1286

(5)Abdugheni, Rashidin; Wang, Wen‐Zhao; Wang, Yu‐Jing; Du, Meng‐Xuan; Liu, Feng‐Lan; Zhou, Nan; Jiang, Cheng‐Ying; Wang, Chang‐Yu; Wu, Lin-Huan; Ma, Jun-Cai;Liu, Chang*; Liu, Shuang‐Jiang*; Metabolite profiling of human‐originated Lachnospiraceae at the strain level, iMeta, 2022, 1(4): e58

(6)Jiang, Yu; Du, Meng-Xuan; Xie, Li-Sheng; Jiang, Min-Zhi; Zhang, Yao-Kun; Bi, Ming-Xia;Liu, Chang*; Liu, Hong-Wei; Liu, Shuang-Jiang*; The human-derived novel gut commensal Luoshenia tenuis regulates body weight and food intake in mice, Food Science and Human Wellness, 2022

(7)Li, Dan-Hua#;Liu, Chang#; Abuduaini, Rexiding; Du, Meng-Xuan; Wang, Yu-Jing; Zhu, Hai- Zhen; Chen, Hong-He; Zhou, Nan; Xin, Yu-Hua; Wu, Lin-Huan; Ma, Jun-Cai; Zhou, Yu-Guang; Lu, Yong; Jiang, Cheng-Ying; Sun, Qiang*; Liu, Shuang-Jiang*; The monkey microbial biobank brings previously uncultivated bioresources for nonhuman primate and human gut microbiomes, mLife, 2022, 1(2): 210- 217

(8)Qiao, Shan-Shan#; Wang, Kai#;Liu, Chang#; Zhou, Nan; Bao, Li; Wang, Jun; Liu, Shuang-Jiang; Liu Hong-Wei; The enriched gut commensal Faeciroseburia intestinalis contributes to the anti- metabolic disorders effects of the Ganoderma meroterpene derivative, Food Science and Human Wellness, 2022, 11(1): 85-96

(9)Li, Dan-Hua; Abuduaini, Rexiding; Du, Meng-Xuan; Wang, Yu-Jing; Chen, Hong-He; Zhou, Nan; Zhu, Hai-Zhen; Lu, Yong; Yu, Pei-Jun; Yang, Yun-Peng; Jiang, Cheng-Ying; Sun, Qiang;Liu, Chang*; Liu, Shuang-Jiang*; Alkaliphilus flagellatus sp. nov., Butyricicoccus intestinisimiae sp. nov., Clostridium mobile sp. nov., Clostridium simiarum sp. nov., Dysosmobacter acutus sp. nov., Paenibacillus brevis sp. nov., Peptoniphilus ovalis sp. nov. and Tissierella simiarum sp. nov., isolated from monkey faeces, International Journal of Systematic and Evolutionary Microbiology, 2022, 72(3)

(10)Liu, Chang; Zhang, Bo; Liu, Yi-Ming; Yang, Ke-Qian; Liu, Shuang-Jiang*; New Intracellular Shikimic Acid Biosensor for Monitoring Shikimate Synthesis in Corynebacterium glutamicum, ACS Synthetic Biology, 2018, 7(2): 591-601

(11)Liu, Chang; Liu, Yi-Ming; Sun, Qing-Lan; Jiang, Cheng-Ying; Liu, Shuang-Jiang*; Unraveling the kinetic diversity of microbial 3-dehydroquinate dehydratases of shikimate pathway, AMB EXPRESS, 2015, 5(7): 7-7

所獲專利

(1)劉雙江;劉暢;杜夢璇;周楠;姜成英;一種藥物候選物對于腸道菌群作用效果的體外高通量篩選平臺, 2020-3-17,中國, 202010186816.3

(2)劉雙江;劉暢;周楠;姜成英;杜夢璇;膽酸衍生物及其應用, 2022-2-22,中國, 202210160201.2

(3)劉雙江;劉暢;杜夢璇;周楠;姜成英;一株小克里斯滕森氏菌SJ-2及其應用, 2021-5-17,中國, 2021105334244.1

(4)劉雙江;劉暢;周楠;姜成英;杜夢璇;膽酸衍生物及其制備, 2022-2-22,中國, 202210160175.3

(5)劉宏偉;劉雙江;劉暢;喬珊珊;代煥琴;韓俊杰;孫敬祖;糞副擬桿菌以及應用, 2021-7-12,中國, 202110786071.9

(6)劉宏偉;劉雙江;喬珊珊;劉暢;羅氏菌MGB-2及其應用, 2021-2-22,中國, 202110176582.9

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