摘要： 代謝綜合征是高血壓、血糖異常、血脂紊亂和肥胖癥等疾病在人體內(nèi)集結(jié)的一組復(fù)雜的代謝紊亂癥候群。茶多酚是茶葉中的特征次生代謝產(chǎn)物之一,最新研究表明,茶多酚可以通過對腸道菌群的干預(yù),改善腸道菌群紊亂,調(diào)節(jié)宿主-腸道菌群的共代謝過程,進而達到改善代謝綜合征的目的。本文系統(tǒng)總結(jié)了茶多酚的吸收與代謝,以及茶多酚在體外發(fā)酵模型、動物試驗和臨床試驗中對腸道菌群的影響,闡述了茶多酚-微生物群-宿主三者之間的內(nèi)在作用機制,有助于以腸道菌群理論為基礎(chǔ)探討茶多酚對人體健康的作用,并為茶多酚的功能性產(chǎn)品開發(fā)提供理論依據(jù)。

關(guān)鍵詞: 茶多酚, 吸收與代謝, 腸道菌群, 代謝綜合征

Abstract: Metabolic syndrome (MS) is an abnormal multi-metabolic disease that comprises a combination of various diseases such as hypertension, abnormal blood sugar, dyslipidemia and obesity. Tea polyphenols (TPs) are the characteristics secondary metabolites in tea leaves. The latest studies show that TPs can improve the disorder of gut flora (GF) and modulate the co-metabolism of Host-GF by the intervention & treatment to achieve the goal of improving MS. This paper systematically summarized the absorption and metabolism of TPs and the effects of TPs on GF in in vitro fermentation models, animal experiments, and clinical trials. The underlying mechanism among TPs-GF-Host was described, which would facilitate further exploring the effects of TPs on human health based on the theory of intestinal flora and developing functional products of TPs. In addition, it also provided theoretical foundation for developing functional products associating with TPs.

Key words: tea polyphenols, absorption and metabolism, gut flora, metabolic syndrome

中圖分類號: 

S571.1

Q946.84+1

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