摘要：

目的： 建立適合中國(guó)人群的凝血四項(xiàng)指標(biāo)[活化部分凝血酶原時(shí)間（activated partial thromboplastin time, APTT）、凝血酶原時(shí)間（prothrombin time, PT）、凝血酶時(shí)間（thrombin time, TT）、纖維蛋白原（fibrinogen, FIB）]參考區(qū)間。方法： 收集來(lái)自上海市東方醫(yī)院(南院)、北京積水潭醫(yī)院、山東省臨沂市中醫(yī)醫(yī)院共計(jì)668例中國(guó)健康成年人，采用cobas t 711平臺(tái)檢測(cè)其凝血四項(xiàng)指標(biāo)，根據(jù)結(jié)果建立參考區(qū)間。結(jié)果： 適合中國(guó)人群的凝血四項(xiàng)指標(biāo)參考區(qū)間為，APTT 26.6~43.6 s，PT 7.67~10.5 s，TT 14.5~19.2 s，F(xiàn)IB 193~419 mg/dL（1 L=10 dL）。凝血四項(xiàng)指標(biāo)在不同性別、年齡和地區(qū)人群間均具有統(tǒng)計(jì)學(xué)差異，性別分析中，PT差異最為顯著（P<0.001），PT和APTT中位數(shù)在男性人群中較高（P<0.01），F(xiàn)IB中位數(shù)在女性人群中較高（P=0.001）。以50歲分組，≤50歲人群與>50歲人群間的PT、TT中位數(shù)差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05），>50歲人群的APTT、FIB中位數(shù)高于≤50歲人群（P<0.005）；不同地區(qū)（上海、北京、山東）間APTT、FIB、PT、TT中位數(shù)差異有統(tǒng)計(jì)學(xué)意義（P<0.001），APTT和FIB中位數(shù)在上海地區(qū)最高，PT中位數(shù)在北京地區(qū)最高，TT中位數(shù)在山東地區(qū)最高。結(jié)論： 本研究建立了中國(guó)健康成年人群的凝血四項(xiàng)指標(biāo)參考區(qū)間，而影響該參考區(qū)間的因素包括地區(qū)、年齡，而男、女間參考區(qū)間相近，提示實(shí)驗(yàn)室應(yīng)根據(jù)自身情況及地區(qū)、年齡來(lái)建立適用的參考區(qū)間。

關(guān)鍵詞: 凝血四項(xiàng)指標(biāo), 參考區(qū)間, 健康中國(guó)成人, 地區(qū), 性別, 年齡

Abstract:

Objective To establish four coagulation indicators suitable for Chinese adults, including activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB). Methods Representative medical institutions from East and North China were selected. A total of 668 Chinese healthy adults were enrolled from Shanghai Oriental Hospital (South Campus), Beijing Jishuitan Hospital and Linyi Hospital of Traditional Chinese Medicine in this study. The cobas t 711 platform was used to detect the four coagulation indicators, and reference intervals were established based on the results. Results The reference interval applicable to all enrolled population was established: APTT (s): 26.6-43.6 s, PT (s): 7.67-10.5, TT (s): 14.5-19.2, FIB (mg/dL): 193-419. The four coagulation indicators were statistically different in different regions, genders and ages. In the gender analysis, difference in PT was the most significant (P<0.001). PT and APTT were higher in the male group, and FIB was higher in the female group; Taking ≤50 years as the cut-off age, APTT, FIB were statistically higher in the elderly group (>50 years old); There were statistical differences in APTT, FIB, PT, and TT in different regions (Shanghai, Beijing, and Shandong) (P<0.001). The median APTT and FIB were highest in Shanghai (P<0.001), the median PT was highest in Beijing (P=0.001), and the median TT was highest in Shandong. Conclusions The reference interval of four coagulation indicators suitable for Chinese healthy adult population is established. Factors that influencing the reference intervals include region and age. Reference intervals between male and female overlaps,and reference intervals establishment depends on laboratory conditions, influencing factors (region, and age) on coagulation management.

Key words: Coagulation indicators, Reference intervals, Healthy Chinese adults, Gender, Age

中圖分類(lèi)號(hào): 

R59

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