摘要： 研究和對比白茶多糖（White tea polysaccharide,WTP）、綠茶多糖（Green tea polysaccharide,GTP）和紅茶多糖（Black tea polysaccharide,BTP）的成分、降血糖效果及機(jī)理。分別選取壽眉、龍井、白琳工夫作為白茶、綠茶和紅茶的代表,測定分析茶多糖提取物的成分和分子量。以鏈脲佐菌素誘導(dǎo)小鼠糖尿病模型,二甲雙胍作為陽性對照,研究茶多糖降血糖效果,qPCR測定小鼠肝臟中相關(guān)基因表達(dá)水平。結(jié)果表明,所選白茶、綠茶和紅茶多糖的絕對重均分子量分別為18 180、19 470、8 745 Da。所選茶多糖提取物均具有降血糖功效,白茶、綠茶和紅茶多糖干預(yù)組小鼠的血糖下降率分別為53.2%、52.8%及61.6%。茶多糖均可改善小鼠葡萄糖耐量,調(diào)節(jié)糖代謝相關(guān)基因表達(dá),并且存在一定差異。

關(guān)鍵詞: 茶多糖, 降血糖, 糖代謝

Abstract: To study and compare the composition, blood sugar lowering effect and composition of WTP, GTP and BTP. Shoumei, Longjing and Bailingongfu were selected as representatives of white tea, green tea and black tea, and the composition, molecular weight of tea polysaccharides were determined. The mice diabetes model was induced by streptozotocin, metformin was used as a positive control to study the hypoglycemic effect of tea polysaccharides, and qPCR was used to determine the expression level of related genes in mice liver. The results showed that the molecular weights of WTP, GTP and BTP are 18 180 Da, 19 470 Da and 8 745 Da, respectively. The selected tea polysaccharides have hypoglycemic effect, the fasting blood glucose decline rates of WTP, GTP and BTP were 53.2%, 52.8% and 61.6%, respectively. Tea polysaccharides can all improve glucose tolerance, down-regulate the expression of Foxo1, G6Pc, PEPCK and TXNIP genes in mice and there are some differences.

Key words: tea polysaccharides, hypoglycemic, sugar metabolism

中圖分類號(hào): 

TS201.4

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