摘要： 目的·探究未服藥神經(jīng)性貪食癥（bulimia nervosa, BN）患者反應(yīng)抑制功能的改變，及其與進(jìn)食障礙癥狀和自評(píng)沖動(dòng)性之間的關(guān)聯(lián)。方法·選擇2018年8月—2019年6月來自上海交通大學(xué)醫(yī)學(xué)院附屬精神衛(wèi)生中心心理咨詢門診的35名未服藥BN患者和招募的23名健康對(duì)照者（healthy controls，HC）作為研究對(duì)象，分別使用中文版進(jìn)食障礙檢查自評(píng)問卷6.0（Eating Disorder Examination Questionnaire 6.0，EDE-Q 6.0）、巴瑞特沖動(dòng)量表（Barrett Impulsiveness Scale-11，BIS-11）比較2組對(duì)象的進(jìn)食障礙癥狀及沖動(dòng)性；使用信號(hào)停止任務(wù)（stop signal task，SST）評(píng)估反應(yīng)抑制能力。對(duì)2組對(duì)象的量表評(píng)分及SST結(jié)果進(jìn)行比較，并研究停止信號(hào)反應(yīng)時(shí)間（stop signal reaction time，SSRT）與BIS-11評(píng)分、EDE-Q 6.0評(píng)分、起病年齡和病程之間的相關(guān)性。結(jié)果·在SST中，與HC組相比BN組SSRT更長（P=0.003）。BN組BIS-11總分（P=0.004）、注意沖動(dòng)分量表評(píng)分（P=0.008）和無計(jì)劃沖動(dòng)分量表評(píng)分（P=0.002）均高于HC組。在BN組SSRT與起病年齡呈正相關(guān)（r=0.503，P=0.006），與EDE-Q 6.0體質(zhì)量顧慮分量表評(píng)分呈負(fù)相關(guān)（r=-0.337，P=0.048），與BIS-11評(píng)分及病程無相關(guān)性。結(jié)論·未服藥BN患者沖動(dòng)性過高，其反應(yīng)抑制缺陷與起病年齡和體質(zhì)量顧慮相關(guān)。

關(guān)鍵詞: 神經(jīng)性貪食癥, 反應(yīng)抑制, 信號(hào)停止任務(wù), 抑制控制, 進(jìn)食障礙

Abstract:

Objective · To investigate the change of response inhibition function in patients with drug-naive bulimia nervosa (BN) and its relationship with eating disorders and self-reporting impulsiveness. Methods · Thirty-five drug-naive BN patients who accepted psychological counseling in Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine between Aug. 2018 and Jun. 2019, and 23 healthy controls (HC) were recruited. The eating disorder and impulsiveness were compared between the two groups by using the Chinese version of Eating Disorder Examination Questionnaire 6.0 (EDE-Q 6.0) and Barrett Impulsiveness Scale-11 (BIS-11), respectively. The stop signal task (SST) was used to assess response inhibition function. The scale scores and SST results were compared between the two groups, and the correlation of stop signal reaction time (SSRT) with BIS-11 score, EDE-Q 6.0 score, the age of onset and the duration of illness was analyzed. Results · Compared with the HC group, the BN group demonstrated significantly longer SSRT in the SST (P=0.003), and had a higher total score of BIS-11 (P=0.004), attentional impulsiveness score (P=0.008) and non-planning impulsiveness score (P=0.002). SSRT was positively associated with the age of onset (r=0.503，P=0.006), negatively associated with the score of weight concern subscale (r=-0.337, P=0.048), and not correlated with the BIS-11 score and the duration of illness in drug-naive BN patients. Conclusion · Drug-naive BN patients have high impulsiveness, and their defects in response inhibition are associated with the age of onset and weight concern.

Key words: bulimia nervosa (BN), response inhibition, stop signal task (SST), inhibitory control, eating disorder

中圖分類號(hào): 

R749.92

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