SCI

12 August 2023

Long-range gene regulation in hormone-dependent cancer 

（nature reviews cancer, IF: 78.5）

Theophilus T. Tettey, Lorenzo Rinaldi & Gordon L. Hager 

CORRESPONDENCE TO: hagerg@exchange.nih.gov 

The human genome is organized into multiple structural layers, ranging from chromosome territories to progressively smaller substructures, such as topologically associating domains (TADs) and chromatin loops. These substructures, collectively referred to as long-range chromatin interactions (LRIs), have a significant role in regulating gene expression. TADs are regions of the genome that harbour groups of genes and regulatory elements that frequently interact with each other and are insulated from other regions, thereby preventing widespread uncontrolled DNA contacts. Chromatin loops formed within TADs through enhancer and promoter interactions are elastic, allowing transcriptional heterogeneity and stochasticity. Over the past decade, it has become evident that the 3D genome structure, also referred to as the chromatin architecture, is central to many transcriptional cellular decisions. In this Review, we delve into the intricate relationship between steroid receptors and LRIs, discussing how steroid receptors interact with and modulate these chromatin interactions. Genetic alterations in the many processes involved in organizing the nuclear architecture are often associated with the development of hormone- dependent cancers. A better understanding of the interplay between architectural proteins and hormone regulatory networks can ultimately be exploited to develop improved approaches for cancer treatment. 

人類基因組由多個結(jié)構(gòu)層組成，從染色體區(qū)域到更小的亞結(jié)構(gòu)，如拓?fù)潢P(guān)聯(lián)域（TAD）和染色質(zhì)環(huán)。這些亞結(jié)構(gòu)統(tǒng)稱為長程染色質(zhì)相互作用（LRIs），在調(diào)控基因表達(dá)方面發(fā)揮著重要作用。TADs是基因組中包含基因組和調(diào)控元件的區(qū)域，這些基因組和調(diào)控元件經(jīng)常相互影響，并與其他區(qū)域隔離，從而防止了DNA的廣泛失控接觸。通過增強子和啟動子相互作用在 TADs 內(nèi)形成的染色質(zhì)環(huán)具有彈性，允許轉(zhuǎn)錄異質(zhì)性和隨機性。在過去十年中，三維基因組結(jié)構(gòu)也稱為染色質(zhì)結(jié)構(gòu)顯然是許多轉(zhuǎn)錄細(xì)胞決定的核心。在本綜述中，我們將深入探討類固醇受體與 LRIs 之間錯綜復(fù)雜的關(guān)系，討論類固醇受體如何與這些染色質(zhì)相互作用并對其進(jìn)行調(diào)節(jié)。涉及核結(jié)構(gòu)組織的許多過程的基因改變往往與激素依賴性癌癥的發(fā)生有關(guān)。更好地了解核結(jié)構(gòu)蛋白與激素調(diào)控網(wǎng)絡(luò)之間的相互作用，最終可以開發(fā)出更好的癌癥治療方法。

本文由“健康號”用戶上傳、授權(quán)發(fā)布，以上內(nèi)容（含文字、圖片、視頻）不代表健康界立場?！敖】堤枴毕敌畔l(fā)布平臺，僅提供信息存儲服務(wù)，如有轉(zhuǎn)載、侵權(quán)等任何問題，請聯(lián)系健康界（jkh@hmkx.cn）處理。

相關(guān)知識

中年女性控肥＝防癌
抗利尿激素分泌失調(diào)綜合癥
Nature綜述：飲食調(diào)整助力癌癥治療
雄性激素分泌失調(diào)怎么辦
DNA酶基因沉默技術(shù)，或可改變癌癥、傳染病的治療
產(chǎn)后產(chǎn)婦的心理調(diào)適中，依賴期多在產(chǎn)后
性激素紊亂
兒童生長激素缺乏癥
最新！中國癌癥報告發(fā)布，它正成為最常見癌癥（不是肺癌）
生長激素缺乏癥

網(wǎng)址: 激素依賴性癌癥中的長程基因調(diào)控 http://www.u1s5d6.cn/newsview335510.html