摘要： 為比較不同原料來源白茶的體外抗氧化和體內(nèi)抗衰老作用并探究其作用機(jī)制,本研究制備白毫銀針（Baihaoyinzhen, YZ）、白牡丹（Baimudan, MD）和壽眉（Shoumei, SM）的提取物,檢測其主要功效成分含量及其體外抗氧化活性。通過誘導(dǎo)D-半乳糖衰老小鼠模型,探究其體內(nèi)抗衰老作用。結(jié)果顯示,YZ提取物的主要功效成分含量均高于MD和SM提取物,SM提取物的茶多酚和總黃酮含量高于MD提取物。在體外,相同濃度下YZ提取物抗氧化能力最強,MD和SM提取物差異不明顯。在體內(nèi),YZ提取物在抑制肝臟脂質(zhì)過氧化方面表現(xiàn)出顯著優(yōu)勢（P<0.05）,SM提取物在提高血清抗氧化酶活性方面具有顯著優(yōu)勢（P<0.05）,但未表現(xiàn)出劑量依賴關(guān)系。3種白茶提取物上調(diào)了小鼠肝臟抗氧化酶與抗衰老基因的表達(dá),表現(xiàn)出劑量依賴性,有效地改善了機(jī)體氧化應(yīng)激狀態(tài),且對小鼠均未表現(xiàn)出肝臟毒性作用。

關(guān)鍵詞: 白茶, D-半乳糖, 抗氧化, 抗衰老, 安全性

Abstract: To in vitro and in vivo evaluate and compare the antioxidant and anti-aging activities of white tea with different sources of raw materials, Baihaoyinzhen (YZ), Baimudan (MD), Shoumei (SM) were prepared and extracted to measure the main efficacy components. In vitro antioxidant assay, the antioxidantβactivitiesβwereβ also tested. For in vivo anti-aging test, the mice were subcutaneously injected with D-galactose and separately orally administered white tea extracts for aging model analysis. The contents of main efficacy components in YZ extract were higher than those in MD and SM extracts. The contents of tea polyphenols and flavonoids in SM extract were higher than those in MD extract. In vitro, YZ extract had better antioxidant capacity, and there was no obvious difference between SM and MD extract. In vivo, the degree of liver lipid peroxidation in YZH and YZL mice were significantly (P<0.05) decreased. The antioxidant enzyme activities were significantly (P<0.05) increased in serum of SMH and SML mice. But it did not show a dose-dependent manner. The 3 kinds of white tea extracts could up-regulate the expression levels of antioxidant enzymes and anti-aging genes to improve the oxidative stress state and it showed a dose-dependent manner. And there was no hepatotoxicity in these group mice.

Key words: white tea, D-galactose, antioxidant, anti-aging, safety

中圖分類號: 

TS272.5+9

相關(guān)知識

“抗氧化等于抗衰老”究竟對不對？
揭秘普洱茶的五大神奇功效與作用：減肥、降脂、抗氧化、抗衰老與提高免疫力
鐵觀音的功效與作用 減肥抗癌抗衰老
抗氧化=抗衰？抗氧化到底抗的是什么
抗衰=抗氧化+抗糖化！精致女生的抗初老攻略！
這么吃真的老得慢！8 種抗氧化食物不僅抗衰老，還能……
茶品也美容：綠茶抗氧 黑茶抗衰 白茶排毒
茶渣蛋白抗氧化肽制備及其活性研究
好茶護(hù)膚：排毒美白抗衰老
抗衰老抗氧化食物有哪些

網(wǎng)址: 白茶體外抗氧化與體內(nèi)抗衰老作用的研究 http://www.u1s5d6.cn/newsview692178.html