Postoperative pain, as a common and significant healthcare issue, has always been the focus of attention in the field of anesthesia for its control and treatment. In the present study, a pH-responsive microneedle (MN) patch is developed for sustained incisional analgesia after surgery. The MN patch has a 10 × 10 MN array within 0.5 cm2 area, and each MN features a complete core-shell structure, with a needle height of ≈850 μm. Upon application, the MNs fully implant in the skin within 15 min due to the rapid dissolution of the water-soluble backing layer. The acidic microenvironment at the surgical site (pH 6.8–7.0) interacts with the pH-reactive medium in the MN shell, triggering the shell rupture. This process enables the smooth release of encapsulated local anesthetic drug (Ropivacaine, Rop) microcrystals, extending local anesthesia duration to over 72 h at a drug concentration of 100 mg mL?1. Additionally, the MN patch intelligently modulates drug release based on the postoperative pain behavior, which correlates with the pH value of the surgical incision microenvironment. This responsive feature results in a prolonged and personalized analgesic effect, addressing the limitations of existing invasive treatments in postoperative pain management.

中文翻譯：

具有自我監(jiān)測能力的 pH 響應(yīng)核殼微針貼片，可實(shí)現(xiàn)局部長效鎮(zhèn)痛

術(shù)后疼痛作為常見且重要的健康問題，其控制和治療一直是麻醉領(lǐng)域關(guān)注的焦點(diǎn)。在本研究中，開發(fā)了一種 pH 響應(yīng)型微針 (MN) 貼片，用于手術(shù)后持續(xù)切口鎮(zhèn)痛。MN貼片在0.5 cm 2面積內(nèi)具有10 × 10 MN陣列，每個(gè)MN具有完整的核殼結(jié)構(gòu)，針高約850 μm。使用后，由于水溶性背襯層的快速溶解，MN 在 15 分鐘內(nèi)完全植入皮膚。手術(shù)部位的酸性微環(huán)境（pH 6.8-7.0）與 MN 殼中的 pH 反應(yīng)介質(zhì)相互作用，引發(fā)殼破裂。該過程使得封裝的局部麻醉藥物（羅哌卡因，Rop）微晶能夠順利釋放，在藥物濃度為100 mg mL -1時(shí)將局部麻醉持續(xù)時(shí)間延長至72 h以上。此外，MN 貼片根據(jù)術(shù)后疼痛行為智能調(diào)節(jié)藥物釋放，這與手術(shù)切口微環(huán)境的 pH 值相關(guān)。這種響應(yīng)特性可產(chǎn)生持久且個(gè)性化的鎮(zhèn)痛效果，解決了術(shù)后疼痛管理中現(xiàn)有侵入性治療的局限性。

相關(guān)知識(shí)

A pH
下列說法不正確的是（ ）A. 人體中血漿的PH為7.35～7.45，則身體健康B. 正常雨水的PH≈5.6C. 廁所清潔劑的PH小于7D. 農(nóng)作物一般適宜在PH=7或接近7的土壤中生長
PH
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6．健康人血液的pH總是維持在7.35
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??自測頭皮PH值｜調(diào)節(jié)頭皮酸堿度｜PH對比
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陰道pH值是多少

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