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醫(yī)學影像英語每日讀丨92.SCI論文摘要解讀

來源：泰然健康網時間：2024年12月17日 06:20

每天朗讀一段醫(yī)學影像學英語文章

朗讀者：Karen老師領讀

Alterations of mean diffusivity of pedunculopontine nucleus pathway in Parkinson's disease patients with freezing of gait.

Abstract

BACKGROUND:

Although freezing of gait (FOG) is a common and disabling symptom in Parkinson's disease (PD), the underlying mechanism of FOG has not been clearly elucidated. Using analysis of diffusion tensor imaging (DTI), we investigated anatomic structures associated with FOG in PD patients.

METHODS:

We enrolled 33 controls and 42 PD patients (19 patients with FOG and 23 without FOG). DTI data were compared between PD patients and controls, and also between PD patients with and without FOG. Whole brain voxel-based analysis and regions of interest analysis in the pedunculopontine nucleus were used for DTI analysis.

RESULTS:

Compared with normal controls, PD patients showed microstructural changes in various subcortical structures (substantia nigra, globus pallidum and thalamus), frontal and insula cortex. PD patients with FOG demonstrated altered mean diffusivities in subcortical structures connected with pedunculopontine nucleus, such as basal ganglia, thalamus and cerebellum in voxel-based analysis. Using region of interest analysis of pedunculopontine nucleus, fractional anisotropy values were reduced and mean diffusivity values were increased bilaterally in PD patients with FOG. In correlation analysis, the fractional anisotropy value of the right pedunculopontine nucleus was moderately correlated with the severity of FOG.

CONCLUSIONS:

Based on our results, microstructural changes of pedunculopontine nucleus and connected subcortical structures are closely related with FOG in PD patients.

帕金森病凍結步態(tài)患者腦橋神經核通路平均擴散速率的改變

摘要

背景：

盡管凍結步態(tài)（FOG）是帕金森?。≒D）中常見的致殘性癥狀，但FOG的潛在機制尚未明確闡明。我們采用擴散張量成像（DTI）分析來研究PD患者中與FOG相關的解剖結構。

方法：

我們招募了33名對照組和42名PD患者（19名為FOG的患者，23名患者無FOG）。比較PD患者和對照之間的DTI數據，以及FOG（+）與FOG（-）的PD患者之間的DTI數據。采用基于體素的全腦分析和感興趣區(qū)分析對腦橋神經核進行DTI分析。

結果：

與正常對照組相比，PD患者在不同皮層下部位（黑質，蒼白球和丘腦），額葉和島葉皮質中顯示出微結構改變。在基于體素的分析中，FOG（+）PD患者在與橋神經核連接的皮層下部位（例如基底神經節(jié)，丘腦和小腦）表現出平均擴散速率的改變。在感興趣區(qū)分析中，FOG(+)PD患者腦橋神經核表現出其雙側各向異性分數值減少和平均擴散值增加。在相關分析中，右側腦橋神經核的各向異性分數值與FOG的嚴重程度呈中等相關。

結論：

基于我們的結果，腦橋神經核和連接的皮層下結構的微觀結構變化與PD患者的FOG密切相關。

來源：每天朗讀一段醫(yī)學影像學英語文章

圈主

深圳市人民醫(yī)院放射科副主任醫(yī)師楊敏潔

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